You can see Sourmash in action in our protocol here

Compute, compare, manipulate, and analyze MinHash sketches of DNA sequences.

Usage instructions:
    Basic operations
        sourmash compare --help   compare sequence signatures made by compute
        sourmash compute --help   compute sequence signatures for inputs
        sourmash gather --help    search a metagenome signature against dbs
        sourmash index --help     index signatures for rapid search
        sourmash info --help      display sourmash version and other information
        sourmash plot --help      plot distance matrix made by 'compare'
        sourmash search --help    search a signature against other signatures

    Taxonomic operations
        sourmash lca --help

    Manipulate signature files
        sourmash sig --help
        sourmash signature --help

    Operations on storage
        sourmash storage --help

  -h, --help     show this help message and exit
  -v, --version  show program's version number and exit
  -q, --quiet    don't print citation information